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Fel d 1
Fel d 1 is a protein that in cats is encoded by the ''CH1'' (chain 1/Fel d 1-A) and ''CH2'' (chain 2/Fel d 1-B) genes.
Fel d 1, produced largely in cat saliva and sebaceous glands, is the primary allergen present on cats and kittens.〔 Fel d 1 is also produced by cat skin itself. The protein is of an unknown function to the animal but causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response). Removal of soft surfaces in the home (carpet, furniture), frequent washings of bed linens, HEPA filters and even washing cats has been proven to reduce the amounts of Fel d 1 present in the home.
Neutered males produce Fel d 1 in levels similar to females (both intact and spayed females produce Fel d 1 in similar levels). Even though females and neutered males produce Fel d 1 in lower levels, they still produce enough to cause allergic symptoms in sensitive individuals.
==Structure==
The complete quaternary structure of Fel d 1 has been determined.〔 The allergen is a tetrameric glycoprotein consisting of two disulfide-linked heterodimers of [chains 1 and 2. Fel d 1 chains 1 and 2 share structural similarity with uteroglobin, a secretoglobin superfamily member; chain 2 is a glycoprotein with N-linked oligosaccharides. Both chains share an all alpha-helical structure.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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